Life Science Rsch Prof 3
Company: Stanford University
Location: Stanford
Posted on: November 4, 2024
Job Description:
The Laboratory of Jesse Engreitz (Dept of Genetics, BASE
Initiative) are seeking a Research Scientist (Life Science Research
Professional 3) focusing on human genetics, genome editing, and
genomics to lead a project to understand the genetic basis of heart
diseases. The Engreitz Laboatory is located in the Biomedical
Innovations Building on the main campus at Stanford University and
are members of the BASE Initiative in the Betty Irene Moore
Children's Heart Center.Project overview: DNA regulatory elements
in the human genome, which harbor thousands of genetic risk
variants for common and rare heart diseases and could reveal
targets for therapeutics that aim to precisely tune cellular
functions - if only we could map the complex regulatory wiring that
connects 2 million regulatory elements with 21,000 genes, and genes
with thousaunds of pathways across the diverse cell types in the
human body. We have recently developed new approaches that could
enable mapping this regulatory wiring at massive scale (see Fulco
et al. Science 2016, Fulco et al. Nat Genet 2019, Nasser et al.
Nature 2021, Gschwind et al. bioRxiv 2023), and applied these and
other approaches to understand the genetic basis of complex
diseases (e.g., Schnitzler et al. Nature 2024). We have now
identified enhancers that contain disease variants that affect risk
for diverse cardiovascular diseases and traits, and aim to study
the functions of these enhancers in human cellular models. These
studies will ultimately help to uncover biological mechanisms of
congenital heart defects, and help to guide diagnosis and treatment
for children with heart disease. For information and recent work,
see https://www.engreitzlab.org and
https://med.stanford.edu/base.htmlWe are looking for a creative and
passionate Research Scientist (PhD-level) to lead the next phase of
our efforts to systematically perturb the genome to understand
genome function and phenotype. The ideal candidate would lead
independent projects, design and supervise large-scale CRISPR data
generation projects, and contribute to managing collaborations
between the Engreitz Lab and NIH-led consortia. The Engreitz Lab
provides a dynamic, interdisciplinary workplace with unique access
to cutting edge technologies and scientific thought, with the
potential for widespread recognition of scientific contributions.
We value a diversity of values, backgrounds, and approaches to
solving problems.The candidate for this position should have
hands-on experience in cellular genomics, molecular biology, and
technology development; experience with quantitative data analysis;
curiosity in research and creativity in problem-solving; strong
interpersonal and collaboration skills; experience building or
managing teams; outstanding verbal and written communication
abilities; ability to adapt to and effectively manage changes in a
fast paced and dynamic environment; and have a passion for science
and sense of urgency to find new medicines to benefit patients.In
addition to submitting your application via the Stanford web
portal, please email your CV and cover letter directly to Prof.
Jesse Engreitz (engreitz@stanford.edu). Duties include:
Make fundamental discoveries about
gene regulation and the genetics of cardiovascular diseaseTogether
with PI and other lab members, design and execute scientific
projects Develop and apply strategies to study enhancers and genes
in human cells and mouse modelsEvaluate and recommend new emerging
technologies, approaches, and problemsSupervise, train, and
collaborate with other lab members in experimental techniques,
scientific design, and other skillsDesign and lead independent
projectsCollaborate with a team of experimentalists and
computational biologistsCreate scientifically rigorous
visualizations, communications, and presentations of
resultsContribute to generation of protocols, publications, and
intellectual property* - Other duties may also be assignedThe
expected pay range for this position is $93,062.00 to $111,670.00
per annum. Stanford University provides pay ranges representing its
good faith estimate of what the university reasonably expects to
pay for a position. The pay offered to a selected candidate will be
determined based on factors such as (but not limited to) the scope
and responsibilities of the position, the qualifications of the
selected candidate, departmental budget availability, internal
equity, geographic location and external market pay for comparable
jobs.At Stanford University, base pay represents only one aspect of
the comprehensive rewards package. The Cardinal at Work website
(https://cardinalatwork.stanford.edu/benefits-rewards) provides
detailed information on Stanford's extensive range of benefits and
rewards offered to employees. Specifics about the rewards package
for this position may be discussed during the hiring process.
DESIRED QUALIFICATIONS:
Ph.D. in Biology, Biochemistry,
Biophysics, Genetics, Bioengineering, Developmental Biology, or
related life science field is preferred. Highly motivated
candidates of all levels are encouraged to apply.Expert in
genomics, technology development, molecular biology, genomics, and
cellular assay development Experience with quantitative data
analysisExperience with CRISPR targeting ES/iPS cells or
single-cell technologies a plusExperience in multidisciplinary
collaborations, management, and/or supervisionCuriosity in research
and creativity in problem-solvingA great team member with strong
interpersonal and collaboration skills Outstanding verbal and
written communication abilitiesAbility to adapt to and effectively
manage changes in a fast paced and dynamic environmentA passion for
science and sense of urgency to find new medicines to benefit
patientsEDUCATION & EXPERIENCE (REQUIRED):
Bachelor's degree in related
scientific field and four years of relevant work experience; or
Master's degree in a related scientific field and two years
relevant experience; or PhD in related science field.KNOWLEDGE,
SKILLS AND ABILITIES (REQUIRED):
Comprehensive understanding of
scientific principles.Expert level knowledge and skills in field of
science related to research project.General computer skills and
experience with databases and scientific applicationsStrong
analytical skills and excellent judgment.Ability to work under
deadlines with general guidance is essential.Excellent
organizational skills and demonstrated ability to complete detailed
work accurately.Developing project management skills.PHYSICAL
REQUIREMENTS*:
Frequently stand, walk, twist, bend,
stoop, squat, grasp lightly, use fine manipulation, grasp
forcefully, perform desk-based computer tasks, use telephone, write
by hand, lift, carry, push and pull objects weighing over 40
pounds.Occasionally sit, kneel, crawl, reach and work above
shoulders, sort and file paperwork or parts.Rarely climb, scrub,
sweep, mop, chop and mix or operate hand and foot controls.Must
have correctible vision to perform duties of the job.Ability to
bend, squat, kneel, stand, reach above shoulder level, and move on
hard surfaces for up to eight hours.Ability to lift heavy objects
weighing up to 50 pounds.Position may require repetitive
motion.
* - Consistent with its obligations under the law, the University
will provide reasonable accommodation to any employee with a
disability who requires accommodation to perform the essential
functions of his or her job.WORKING CONDITIONS:
May require working in close
proximity to blood borne pathogens.May require work in an
environment where animals are used for teaching and
research.Position may at times require the employee to work with or
be in areas where hazardous materials and/or infectious diseases
are present.Employee must perform tasks that require the use of
personal protective equipment, such as safety glasses and shoes,
protective clothing and gloves, and possibly a respirator.May
require extended or unusual work hours based on research
requirements and business needs.
Keywords: Stanford University, Fremont , Life Science Rsch Prof 3, Other , Stanford, California
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